Research Scientist

This position supports the research program of Dr. Rachael Gordon in the Division of Rheumatology and Clinical Immunology at the University of Pittsburgh. Dr. Gordon's program focuses on understanding the immunopathogenesis of Sjgren's disease (SjD) with the goal of identifying new therapeutic targets. The research program uses murine models of SjD, multiomics technologies, and a prospective SjD patient registry and biorepository to study novel pathogenic immune pathways, including the IL-12/IFN axis and infectious triggers of autoimmunity. The Research Scientist will be expected to work independently, exercise scientific judgment across all aspects of the research program, and play a central role in driving projects forward from conception through publication.

Preferred qualifications include a PhD, MD/PhD, or equivalent professional doctorate in immunology, microbiology, or a related biomedical discipline, with a minimum of 5 years of relevant research experience and a track record of independent scientific productivity including peer-reviewed publications. Preferred technical experience includes in vivo mouse models of autoimmune or inflammatory disease, multiparameter or spectral flow cytometry, and human biospecimen processing. Experience with multiomics platforms such as single-cell RNA sequencing, spatial transcriptomics, bulk RNA sequencing, or proteomics is strongly preferred, and the ability to independently analyze such datasets is a plus. Experience with human translational research is also advantageous. The ideal candidate will have strong problem-solving skills, clear scientific communication, and the ability to work both independently and as part of a collaborative, multidisciplinary team.

Conducts independent scientific research projects from inception to presentation. Prepares and crafts various documentations of research results into manuscripts, proposals, grant applications, and presentations. Trains undergraduates and research technicians. Manages laboratory policies and coordinates project development in collaboration with other specialists.

• Conducts independent scientific research projects from inception to presentation, including hypothesis generation, experimental design, data collection, analysis, and interpretation
• Independently plans and executes in vivo experiments in murine models of Sjgren's disease, including disease phenotyping, necropsy, and histopathologic assessment
• Independently performs and interprets spectral flow cytometry including panel design and data analysis
• Independently performs standard molecular and cellular biology techniques including ELISA, RT-qPCR, and immunohistochemistry
• Manages transgenic and knockout mouse colonies including breeding, genotyping, and health monitoring
• Collaborates with the SjD registry and biorepository team to support biospecimen processing and protocol development
• Independently or collaboratively interfaces with collaborators/core facilities for multiomics studies including scRNAseq and spatial transcriptomics; independent analysis expertise preferred
• Prepares manuscripts, grant applications, and presentations
• Recommends and manages laboratory policies and standard operating procedures
• Trains and provides scientific mentorship to trainees and laboratory personnel

• Must be able to sit or stand for prolonged periods of time at a laboratory bench or workstation

• Must be able to use a PC or laptop for extended periods for data analysis and reporting

• Must be able to perform repetitive hand and wrist movements associated with pipetting and laboratory bench work

• Must be able to lift and carry laboratory supplies and equipment weighing up to 25 pounds

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