108 Science jobs

US-TN-Nashville Job ID: 2019-7731 Job Type Full-Time Overview Director of Data Science We're SmileDirectClub, and we believe everyone deserves a smile they'll love. We also believe that you deserve a job you'll love. Good thing you found us, and we found you. At SmileDirectClub, we're all about empowering transformation. We want people to become more confident in how they look, how they feel, and how they think. So we're spreading smiles and positivity all over the country. It's no small task. That's why we're looking for energetic, passionate, and confident team members who can help turn frowns into life-changing grins. Are you up for it? The Director of Data Science will focus on improving and automating many aspects of our customer journey, from customer acquisition to fulfillment. In the process, you will have an opportunity to improve our customers' experiences and have a major impact on a thriving business. The ideal candidate is a critical thinker, is passionate about solving problems with data, and is excited about working in a fast-paced, innovative, and successful environment. Responsibilities Responsibilities: Solve business problems by reframing them to enable algorithmic solutions Perform exploratory data analysis to gain a deeper understanding of problems Collaborate closely in an equal partnership with business and engineering teams Write production modeling code; collaborate with Software Engineers to implement algorithms in production Maintain a balance between building principled, mathematically rigorous solutions, and launching things quickly Work with functional leaders to maintain a prioritized backlog and create short-term and long-term goals Instill a spirit of continuous improvement in the team's code, architecture, and processes Work closely with SmileDirectClub's Talent Acquisition team to hire high potential candidates from diverse backgrounds Qualifications Qualifications: An advanced degree in a quantitative field; for example, mathematics, physics, cognitive science, statistics, computer science, etc. At least 2-4 years of experience leading a data science team Theoretical knowledge and experience applying statistical (or machine learning) models to real-life problems Experience tackling vague problems and transforming them into algorithmic solutions End-to-end experience with data, including querying, aggregation, analysis, and visualization Proficiency with querying languages like SQL, as well other programming and scripting languages such as Python and R Experience using modern tools to access large distributed datasets (e.g. Presto, Spark) Willingness to collaborate and communicate with others to solve a problem Scrappiness and can thrive on autonomy Inclined towards thinking ahead and building for the future Benefits of joining the club : Medical, Dental and Vision Insurance 401K with match PTO Aligner and Whitening Benefit Collaborative work environment and positive culture SmileDirectClub was founded on a simple belief: everyone deserves a smile they love. The Company is the first digital brand for straightening your smile, created after the realization that recent trends in 3D printing and telehealth could bring about disruptive change to the invisible aligner market by matching licensed professionals, a quality clear-aligner product, and customers together. By leveraging proprietary, cutting-edge technology, SmileDirectClub, LLC-affiliated dentists are providing greater access of care to consumers who couldn't otherwise afford orthodontic treatment to get a better smile. Who We Are: https://vimeo.com/284966502 https://smiledirectclub.com Benefits of Joining the Club Medical, Dental and Vision Insurance 401K with match PTO Aligner and Whitening Benefit Collaborative work environment and positive culture Company Profile SmileDirectClub was founded on a simple belief: everyone deserves a smile they love. The Company is the first digital brand for straightening your smile, created after the realization that recent trends in 3D printing and telehealth could bring about disruptive change to the invisible aligner market by matching licensed professionals, a quality clear-aligner product, and customers together. By leveraging proprietary, cutting-edge technology, SmileDirectClub, LLC-affiliated dentists are providing greater access of care to consumers who couldn't otherwise afford orthodontic treatment to get a better smile. What is SmileDirectClub? Link here. What are our customers saying? Link here. What is a SmileShop? Link here. What is our culture like? Link here. How do you celebrate your team members? Link here. PI116356511

University of Kentucky Equal Employment Opportunity/M/F/disability/protected veteran status. Posting Details Posting Details Job Title Scientist III Requisition Number RE21576 Working Title Department Name 81060:PLANT AND SOIL SCIENCES Work Location Lexington, KY Grade Level 48 Salary Range $59,613-98,363/year Type of Position Staff Position Time Status Full-Time Required Education PhD Click here for more information about equivalencies: http://www.uky.edu/hr/employment/working-uk/equivalencies Required Related Experience 3 yrs Required License/Registration/Certification None Physical Requirements Position requires some minor lifting of objects and sitting for long periods of time to analyze results of the analysis. Exposure to hazardous chemicals and/or fumes. Shift Primarily days with some evenings and weekends. Job Summary The College of Agriculture, Food and Environment department of Plant and Soil Sciences seeks a Scientist III. The Scientist III will manage the FAPRU mass spectrometry laboratory, and provide expertise on the analysis and chemical composition of the tissues and metabolites of plants, animals, and microorganisms. In addition to developing new analytical methods the position will oversee lab personnel, equipment, supplies, and ensure laboratory safety protocols. Skills / Knowledge / Abilities Skills with mass spectrometry, gas and liquid chromatography Does this position have supervisory responsibilities? No Preferred Education/Experience PhD in Chemistry or related field with at least 10 years of experience with analytical analysis Deadline to Apply 12/22/2019 University Community of Inclusion The University of Kentucky is committed to a diverse and inclusive workforce by ensuring all our students, faculty, and staff work in an environment of openness and acceptance. We strive to foster a community where people of all backgrounds, identities, and perspectives can feel secure and welcome. We also value the well-being of each of our employees and are dedicated to creating a healthy place to work, learn and live. In the interest of maintaining a safe and healthy environment for our students, employees, patients and visitors the University of Kentucky is a Tobacco & Drug Free campus. As an Equal Opportunity Employer, we strongly encourage veterans, individuals with disabilities, women, and all minorities to consider our employment opportunities. Any candidate offered a position may be required to pass pre-employment screenings as mandated by University of Kentucky Human Resources. These screenings may include a national background check and/or drug screen. Posting Specific Questions Required fields are indicated with an asterisk (*). * Where did you first see this position advertised other than on UK's online employment system? InsideHigherEd.com HigherEdJobs.com Diverseeducation.com (Diverse Issues in Higher Education) HERCjobs.org (Higher Education Recruitment Consortium) InsightIntoDiversity.com Latinosinhighered.com Indeed.com A Colleague, Friend and/or Family Member None of the Above Applicant Documents Required Documents Resume Optional Documents Cover Letter PI116338016

Amgen Job ID: R-89780 Location: South San Francisco, CA, US 94083 Amgen is seeking a highly motivated scientist to join the Pharmacokinetics & Drug Metabolism (PKDM) department at our site in South San Francisco, California. Amgen provides a collaborative and creative culture in a company with a strong track record of innovation. Our culture encourages open dialogue and diverse views to land on the best solutions, and we help ensure our staff are equipped to excel today and tomorrow. The department of pharmacokinetics and drug metabolism (PKDM) within Amgen is dedicated to the discovery and development of novel effective, safe medicines. The successful candidate will work in a team environment to characterize the absorption, distribution, metabolism, excretion and pharmacokinetic properties of therapeutic drug candidates to achieve their full pharmacological potential. PKDM works in close partnership with disciplines such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to design promising clinical therapeutic candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings. Job Description The Bio-transformation Principle Scientist leader will be in charge of implementing cutting edge separations and mass spectrometry tools (LC/MS) for the identification, quantitative and qualitative analysis of novel drug candidates and their metabolites from in vitro and in vivo biological matrices. The role will provide opportunity to work with broad range of scientific expertise and leadership across the Research organization. The role will broadly cover biotransformation of small molecules, proteins and RNAi therapeutics. The ideal candidate will have a proven ability to design and execute experiments to conduct metabolite identification, isolation and characterization, have general understanding of enzyme kinetics, and understand clearance mechanism in support of both drug discovery and development programs. This role requires an excellent understanding of preclinical in vivo models, in vitro ADME and bioanalytical techniques. This role is ideally suited for an individual that can work collaboratively in a fast-paced work environment. The candidate should also assist in new technology, strategies, and data processing implementation. Other responsibilities/opportunities will include writing scientific reports, author original scientific manuscripts and present results to project teams or at scientific meetings. Basic Qualifications Doctorate degree and 3 years of Scientific experience OR Master's degree and 6 years of Scientific experience OR Bachelor's degree and 8 years of Scientific experience Preferred Qualifications PhD or MS in chemistry, biochemistry, or equivalent. Experience with operation, troubleshooting, and data interpretation of a mass spectrometer is required. Experience with operation of automated liquid sample handling instruments and experience with analysis of radiolabeled compounds is desired. The candidate should possess excellent oral and written communication skills and be able to excel in a highly collaborative, matrixed team environment. Interactions and collaboration with academic and other external scientists are encouraged. We understand that to successfully sustain and grow as a global enterprise and deliver for patients - we must ensure a diverse and inclusive work environment. Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology. Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential. Join Us If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen. Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance. PI116336384

Amgen Job ID: R-89783 Location: South San Francisco, CA, US 94083 Amgen is seeking a highly motivated scientist to join the Pharmacokinetics & Drug Metabolism (PKDM) department at our site in South San Francisco, California. Amgen provides a collaborative and creative culture in a company with a strong track record of innovation. Our culture encourages open dialogue and diverse views to land on the best solutions, and we help ensure our staff are equipped to excel today and tomorrow. The department of pharmacokinetics and drug metabolism (PKDM) within Amgen is dedicated to the discovery and development of novel, effective, safe medicines. The successful candidate will work in a team environment to characterize the absorption, distribution, metabolism, excretion and pharmacokinetic properties of therapeutic drug candidates to achieve their full pharmacological potential. PKDM works in close partnership with disciplines such as pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to design promising clinical therapeutic candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings. In this role you will add substantial scientific expertise to the discovery and non-clinical development of small molecule therapeutics, with a primary a primary focus on drug transporters. You will be responsible for establishing and optimizing in vitro assays to evaluate new chemical entities as substrates or inhibitors of drug transporters to assess and characterize the role of transporters in drug disposition. In addition, you will make meaningful and innovative contributions to the fundamental understanding of the role of drug transporters as they relate to absorption, distribution, and clearance of small molecule therapeutics. In this position your core responsibilities are to: Serve as a functional representative and subject matter expert on the transport of small molecule therapeutics, collaborating with PBPK scientists across our PKDM scientific community Evaluate and implement emerging in vitro and in silico tools to support the prediction of transporter-mediated pharmacokinetics (PK) and drug interactions (DDIs) in humans Articulate risk and mitigation strategies for human PK and DDI predictions Design and complete IND and NDA-enabling studies and reports to support regulatory submissions Your specific contributions will depend on your expertise, interests, training, and experience. You will also have opportunities to learn and obtain experience with PKDM strategies for the discovery and non-clinical development of biological therapeutics. In addition to the core responsibilities, the position provides the opportunity to pursue scientific inquiries into the fundamental physiological and biochemical factors that determine the absorption, distribution, and clearance of protein therapeutics. A collaborative and highly capable scientific community at Amgen is available to support these efforts. Interactions and collaboration with academic and other external scientists are encouraged. Basic Qualifications Doctorate degree and 3 years of Scientific experience OR Master's degree and 6 years of Scientific experience OR Bachelor's degree and 8 years of Scientific experience Preferred Qualifications A Ph.D. in pharmaceutical, chemical, or biological science (or BA/MS with equivalent experience) and 4+ years of drug discovery and/or development experience. Expertise with implementing, optimizing and troubleshooting in vitro transporter assays. Knowledge of PK and distribution of small molecule therapeutics. Critical thinking, and demonstrated ability to communicate with team members across broad disciplines. Effective oral and written communication skills are essential. We understand that to successfully sustain and grow as a global enterprise and deliver for patients - we must ensure a diverse and inclusive work environment. Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology. Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential. Join Us If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen. Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance. PI116336450

Amgen Job ID: R-89993 Location: Thousand Oaks, CA, US 91360 The Biostatistics Mgr will ensure all statistical aspects pertaining to clinical activities meet required standards and are statistically correct Influencing study design, and defending statistical approaches internally and externally Leading one complex or multiple less complex studies/projects Adhering to all Amgen Policies, SOPs and other controlled documents Key activities include: Providing statistical contributions, statistical review and quality control of Key Design Elements (KDE) protocols, randomization specifications, Statistical Analysis Plans (SAPs), Table, Listing and Graph (TLG) shells, Submission Data File (SDF) specifications, other key-study related documentation, protocol deviations, Flash Memos, Clinical Study Reports (CSRs), clinical publications, and other communications Completing statistical analysis of individual studies/projects Publishing applied research in scientific journals and books, and give presentations on statistical methodology in the biopharmaceutical setting at external scientific meetings (biopharmaceutical industry and academic meetings) Being familiar with statistical policy and strategy at Amgen Staying abreast of latest developments in the field of statistics in drug development and contribute to scientific advances in the field Communicating the role of the Global Biostatistics department, and may contribute to statistical training within Global Biostatistics and within Amgen Assisting in the review of Amgen Policies, SOPs and other controlled documents Assisting with study and systems audits conducted by Amgen CQA and external bodies Serving as team member of change / process improvement initiatives" Basic Qualifications: Doctoral degree in Statistics/Biostatistics or other subject with high statistical content OR Currently enrolled in PhD program in Statistics/Biostatistics or other subject matter with high statistical content, and must complete all requirements necessary to obtain Doctoral Degree in the PhD program prior to employment start date OR Master's degree in Statistics/Biostatistics or other subject with high statistical content and 3 years of statistics experience Preferred Qualifications: Doctorate degree in statistics or biostatistics Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology. Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. Join Us If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen. Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. PI116336555

Amgen Job ID: R-88694 Location: Thousand Oaks, CA, US 91360 We are seeking a highly motivated individual who will support the digital transformation of Amgen Operations by leveraging advanced analytics to characterize business performance in Operations, evaluate potential opportunities, and enable step change in business performance. The ideal candidate will leverage his/her quantitative expertise to challenge the status quo, drive automation and continuous improvement, and embed digital ways of working in Operations. The role will be responsible for providing analytical support and enabling data-driven decision making that will build foundational capability to provide end-to-end visibility into business processes and build advanced analytics solutions to drive value. In addition to focusing on solving traditional and big data problems, this role will be support our Data Management and Governance programs, Data Architecture and Modeling, and the overall data footprint. This role will interact with a wide range of business leaders to understand processes, analyze data, and present findings. Job Responsibilities: Assist in cross functional analytics projects from beginning to end: from building relationships with key business leaders to collecting and analyzing data, as well as summarize and present key insights in support of decision making to help evaluate strategic options that support data and analytics transformation Use analytics tools and scientific rigor to produce actionable insights Assist in the development of a wide-range of innovative data and analytics solutions, from descriptive to machine learning based (including real-time visualization tools that leverage Big Data platforms with real-time data ingestion and processing) Collaborate with business leaders, subject matter experts, and decision makers to develop success criteria and optimize analytics solutions across Operations Partner with business to share data best practices and support business / IS led implementation Assist in developing business cases and strategic recommendations Interact with various finance groups including functional FP&A to understand impact to budget/long range plans Provide support in developing executive communications and present analysis and insights to Amgen's senior leadership Perform ad hoc analysis and support special projects Basic Qualifications: Master's degree OR Bachelor's degree and 2 years of data science, business, statistics, data mining, applied mathematics, business analytics, engineering, computer science or related field experience OR Associate's degree and 6 years of data science, business, statistics, data mining, applied mathematics, business analytics, engineering, computer science or related field experience OR High school diploma / GED and 8 years of data science, business, statistics, data mining, applied mathematics, business analytics, engineering, computer science or related field experience Preferred Qualifications: Master's degree in data science, business, statistics, data mining, applied mathematics, business analytics, engineering, computer science or related field and 1 year of relevant experience in developing advanced analytics algorithms and analyzing data specifically in Operations (BioPharma Operations a plus) Understanding of / experience in Operations, including Supply Chain, Manufacturing, Engineering, etc. Statistical or mathematical modeling experience Ability to work with unstructured data sets and harmonize complex Operations data Familiarity with common Operations systems, such as SAP, Rapid Response, MES, LIMS, etc. Familiarity with advanced analytics tool sets, such as R, Python, SQL, Alteryx, etc. Experience processing, filtering, and presenting large quantities of data stored in data warehouse or data lake repositories and data extracted directly from the source systems Experience with data visualization tools or packages, such as Tableau or Spotfire Experience working on a cloud platform (e.g., AWS, Azure, etc.) is a plus Familiarity using Dev Ops technologies Ability to communicate and collaborate cross-functionally in an organization Energetic, detailed oriented, highly motivated with a "can do" outlook Proven ability to work effectively in ambiguous situations Ability to manage multiple projects concurrently Join Us If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen. Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. PI116336745

Amgen Job ID: R-89867 Location: Thousand Oaks, CA, US 91360 Amgen is seeking a Process Development Scientist within our Pre-Pivotal Bioprocess Development team, to be based in our Thousand Oaks, CA office. You will lead laboratory-focused projects, collaborating with cell culture and purification scientists who develop robust clinical processes to advance Amgen's biologics pipeline. As part of this opportunity, you will develop strong technical skills, work in cross-functional teams, and mentor junior staff in career development. The scope of work and responsibility span protein construct selection, clinical process development, support of technology transfer, authoring regulatory CMC documents, and interacting with regulatory agencies. In addition, you will lead and support efforts to develop and implement new technologies and new business strategies to drive organizational efficiency. This organization develops, characterizes and supports the production of the drug substance manufacturing processes for all early-stage programs across the Amgen portfolio, enabling advancement of programs from pre-clinical through Ph I/II clinical trials. Responsibilities include: • Independently authors technical reports, regulatory filings, patents, peer reviewed publications and actively participates in scientific conferences • Conveys information and makes recommendations on scientific issues to senior management • Develops technology to deliver multi-kilogram quantities of drug substance in a safe, practical and efficient manner • Provides significant contributions to drug substance development teams (e.g., product, process development and product quality teams) by providing drug substance updates, documentation, data interpretation, technical recommendations, etc. • Serves as a technical authority and keeps current in relevant literature and related technology with a record of successful application of said technology complying to current and emerging regulatory requirements (FDA, EMA, ICH, etc) • Works cross-functionally to author CMC regulatory documents and documentation in support of Amgen's regulatory filings • Develops processes amenable to cGMP operation and leads deliveries of drug substance in a cGMP manufacturing environment in both internal and external capacity for batch and continuous processes • Ensures that safe laboratory practices are followed. • Provides mentoring and expertise to less-experienced staff Basic Qualifications: Doctorate degree OR Master's degree and 3 years of scientific experience OR Bachelor's degree and 5 years of scientific experience OR Associate's degree and 10 years of scientific experience OR High school diploma / GED and 12 years of scientific experience Preferred Qualifications: • Doctorate in biological science discipline or chemical engineering with 2+ years of experience • Expertise and experience in mammalian cell culture and/or purification process development • Extensive experience in development and/or support of bio-manufacturing processes, including process scale-up and GMP production • Experience in CMC clinical and commercialization process • Track record of innovation and implementation of new technologies • Experience in authoring IND sections and interaction with regulatory agencies Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology. We understand that to successfully sustain and grow as a global enterprise and deliver for patients - we must ensure a diverse and inclusive work environment. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. Join Us If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen. Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. PI116336144

Alexion Pharmaceuticals, Inc. Alexion is an Equal Opportunity/Affirmative Action Employer. Req ID: 16915 Job Category: Process Development Location: New Haven, CT Posting Date: December 13, 2019 Attention: If you are a current Alexion employee, please apply via Alexion's internal Life & Career portal . Note that you will need to be connected to the VPN if you are applying away from the office. Alexion does not contact candidates via instant messaging or chat tools. At no time will we ask candidates for fees associated with obtaining software, nor do we provide employees with a cashier's check to purchase new equipment. If you are contacted in this manner, please be aware that it is fraudulent, and please do not provide any information or money to these individuals. Applicants should only apply through this Alexion website. Any fraudulent activity should be reported to GSOC@alexion.com Position Summary This candidate is required to plan and execute studies towards pharmaceutical development to support programs for preclinical, clinical and commercial stage molecules. Familiarity with biophysical methods, commonly used in early formulation development and automation is highly desirable. The candidate is required to plan and execute formulation development studies, as well as clinical materials compatibility and dosing solution stability evaluation. The responsibilities will also include technical support of the drug candidates frozen storage, as well as other aspects of product life cycle optimization. The responsibilities will also include limited method development and optimization for the assays, specific for pharmaceutical development of biotherapeutics. In addition, this position is expected to interact regularly with scientific staff within Global Analytical Sciences and Pharmaceutical Development (GAPD). The ability to accurately and independently generate procedures, protocols, reports, and CMC section content for regulatory filings pertaining to formulation development, stress testing, pharmaceutical support studies, stability and test methods is required. Principal Responsibilities Design and execute pre-formulation screening and pharmaceutical development studies for preclinical, clinical and commercial stage biopharmaceuticals (45%) Design and execute clinical material compatibility and dosing solution stability studies for clinical product candidates as well as commercial products as required (15%) Author technical reports for the development, implementation of test methods, support submissions for IND and BLA and draft reports for regulatory filing (10%) Manage stability studies for clinical development candidates. (5%) Analyze and interpret analytical data. (5%) Support technical transfer and validation activities (5%) Participate in cross-functional process development teams representing Pharmaceutical Development (5%) Seek out and evaluate new instruments, methods, techniques and technology platforms to enhance formulation and analytical operations (5%) Present results in internal and external meetings (5%) Qualifications PhD with 0-3 years, or MSc with at least 10 years of suitable experience in pharmaceutical sciences, biochemistry, chemistry, biophysics or other relevant discipline or in a pharmaceutical development capacity in the pharmaceutical or biotech industry Scientific understanding of factors impacting protein stability. Position requires scientific and practical knowledge of general test methods for analyzing protein therapeutics including monoclonal antibodies and glycoproteins. Position requires an overall understanding of protein degradation pathways and expertise in the analytics to identify and track such degradants as well as to formulate around such issues. Experience with assay development, optimization, qualification and validation for protein therapeutics is a significant plus. Ability to take initiative in problem solving. The individual must be able to work in a collaborative setting. Ability to adhere to timelines is essential. Knowledge of cGMP and quality guidelines Excellent interpersonal skills are required, as is the strong ability to communicate effectively Education Successful candidate will have obtained a degree in pharmaceutical sciences, biochemistry, biological sciences, chemistry or other relevant discipline and have worked in the pharmaceutical or biotechnology industry in a pharmaceutical development capacity for following period; PhD, 0-3 years MSc, at least 10 years *LI-DI1 New Haven, CT, United States Some opportunities happen only once in a lifetime - like a job where you have the extraordinary opportunity to change lives. At Alexion, such opportunities arise through our unwavering mission to serve patients and families affected by rare diseases. These patients are our guiding star, and we act with integrity, urgency, and discipline because we know their lives are at stake. Alexion is a global biopharmaceutical company focused on serving patients and families affected by rare diseases through the discovery, development and commercialization of life-changing therapies. As the global leader in complement biology and inhibition for more than 20 years, Alexion has developed and commercializes two approved complement inhibitors to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) as well as the first and only approved complement inhibitor to treat atypical hemolytic uremic syndrome (aHUS), anti-acetylcholine receptor (AchR) antibody-positive generalized myasthenia gravis (gMG) and neuromyelitis optica spectrum disorder (NMOSD). Alexion also has two highly innovative enzyme replacement therapies for patients with life-threatening and ultra-rare metabolic disorders, hypophosphatasia (HPP) and lysosomal acid lipase deficiency (LAL-D). In addition, the company is developing several mid-to-late-stage therapies, including a second complement inhibitor, a copper-binding agent for Wilson disease and an anti-neonatal Fc receptor (FcRn) antibody for rare Immunoglobulin G (IgG)-mediated diseases as well as several early-stage therapies, including one for light chain (AL) amyloidosis and a second anti-FcRn therapy. Alexion focuses its research efforts on novel molecules and targets in the complement cascade and its development efforts on the core therapeutic areas of hematology, nephrology, neurology, and metabolic disorders. Alexion has been named to the Forbes' list of the World's Most Innovative Companies seven years in a row and is headquartered in Boston, Massachusetts' Innovation District. The company also has offices around the globe and serves patients in more than 50 countries. Further information about Alexion can be found at: www.alexion.com. As a leading employer in our industry, Alexion is proud to offer a highly competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. Alexion participates in E-Verify process. To learn more, please click on attached document(s) English / Spanish PI116335603

Gryphon Technologies, LC Senior Synthetic Biologist / Materials Scientist US-VA-Arlington Job ID: 2019-6198 Type: Regular Full-Time (100% or 75%) # of Openings: 1 Category: Technology Advisory Services 675 N Randolph St. Overview Gryphon Technologies, Inc. (Gryphon) is a premier engineering and technical services provider supporting National Security programs. Gryphon is the federal Government’s partner working in support of mission critical systems in every phase of their lifecycle. We are proud of our ability to help shape tomorrow, while ensuring today’s U.S. and coalition forces can carry out their critical missions and tasks. Gryphon is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. Responsibilities We provide Scientific, Engineering and Technical Assistance (SETA) support to Defense Advanced Research Projects Agency (DARPA) in Arlington, VA. For sixty years, DARPA has held to a singular and enduring mission: to make pivotal investments in breakthrough technologies for national security. We have an immediate need for a Senior Synthetic Biologist / Materials Scientist to support the Biological Technologies Office at DARPA in Arlington, VA. The candidate will support the development and management of current and planned programs involving synthetic biology, therapeutics, and/or materials science and engineering. Planned programs aim to develop systems, based on advanced materials, for scarce resource harvesting (e.g., water, REEs, etc.). Other planned programs aim to develop therapeutic modalities to improve readiness and performance of Warfighters. Ideal candidates will have experience in synthetic biology, therapeutics, and/or materials science/chemistry/engineering. Qualifications REQUIRED EXPERIENCE: Secret DoD Security Clerance Ph.D. in in a field relevant to the support of synthetic biology or materials science Strong technical writing skills, ability to communicate complex scientific ideas to broad audiences, digest basic and applied research across areas of biotechnology and apply to defense capability gaps Ability to handle a wide variety of tasks, to include briefing development in PowerPoint and general administrative tasks One must have good written communication, interpersonal, problem-solving, analytical, mathematical, and organizational skills. Ability to follow directions is a must. Applicants must be able to work well alone and as part of a team. A Security Clearance or the ability to obtain one will be required. U.S. Citizenship required. PI116301107

Otsuka Neuroscience Account Mgr US--Remote Sales Job ID: 2019-11087 Type: Full time # of Openings: 1 Category: Field Sales Otsuka Overview At Otsuka, we defy limitation, so that others can too. We have an unwavering belief in doing more. In transcending expectations. In going above and beyond—under any circumstances—for patients, families, providers, and for each other. It's this deep-rooted dedication that drives us to uncover answers to complex, underserved medical needs, so that patients can push past the limitations of their disease and achieve more than they thought was possible each and every day. We believe that the bigger the challenge, the bigger the opportunity. We are doing everything in our power to live up to our mission of creating new products for better health worldwide in two important therapeutic categories: neuroscience and nephrology. Our culture is rooted in our Japanese heritage and almost 100-year history. Otsuka-people live by the core principles of Jissho – the achievement, completion, and discovery of truth; and Sozosei – pursuing that which only Otsuka is capable of delivering. We approach our business and overcome challenges through perseverance, unconventional thinking and humility. Learn more about Otsuka Pharmaceutical Company on its global website at http://www.otsuka.co.jp/en . Learn more about Otsuka in the U.S. at www.otsuka-us.com . Disclaimer: This job description is intended to describe the general nature and level of the work being performed by the people assigned to this position. It is not intended to include every job duty and responsibility specific to the position. Otsuka reserves the right to amend and change responsibilities to meet business and organizational needs as necessary. Otsuka is an equal opportunity employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to their protected veteran or disabled status, or any protected status. Responsibilities We are committed to mental health and looking for Account Managers who share our passion to support the promotion and co-promotion of neuroscience products. Over the years, our innovations in schizophrenia and major depressive disorder (MDD) have advanced, and our knowledge of other mental health illnesses and disorders continues to grow. We are looking for individuals who are highly motivated, learning agile, and can grow in a Commercial organization. Otsuka-people who: Think differently by challenging conventional thinking Are intellectually curious and life-long learners Are effective, 'get it done' and have a sense of ownership Are comfortable with ambiguity, autonomy and recognize that innovation is at its best when people connect Are remarkable in their chosen field Key Job Expectations/Responsibilities: Can be counted on to exceed goals successfully, very bottom-line oriented, steadfastly pushes self and others for results Can quickly find common ground and solve problems for the good of all, can represent his/her own interests and yet be fair to others, can solve problems with peers, direct reports and matrix team members with a minimum of noise, is seen as a team player and is cooperative, easily gains trust and support of colleagues, encourages collaboration Summarizes complex situations or data sets into easily understood information Makes decisions using information gathered and develops others in their ability to organize their thoughts, identify patterns in data, and facilitate decision making Continually analyzes performance against plan and is proactive in planning sales activities to maximize customer calls and impact Evaluates the results of timelines and resource plans and recommends changes Coordinates with alliance company sales management team within region geography Manages key account coordination along with the District Managers to develop relationships leading to increased profitability and better patient outcomes Ability to sell a portfolio of products Compliance Management: Ensures full and complete compliance of all selling activities within the area of responsibility to OAPI standards and to all state and federal regulations Complies with the letter and spirit of all state and federal laws, regulations, and guidance as well as PhRMA Code on Interactions with Healthcare Professionals and OAPI standards and policies relating to all promotional activities Qualifications Required: 2 years of pharmaceutical sales experience and/OR 3-5 years of business to business outside sales experience Minimum of 1 year ranked in top 25% with overall sales Able to provide last 2 years of performance review documentation Willing to un-learn entrenched ways of doing things Ability to learn new and complex materials and concepts Demonstration of customer focus or patient centricity Thinks strategically; intuitively makes connections and associations Communicates effectively; strong and engaging facilitator Demonstrates managerial courage and strong professional presence Humility Bachelor of Arts (BA) or Bachelor of Science (BS) degree from an accredited four year college or university (or the equivalent if education obtained outside of the United States) Valid Driver's license and a good driving record under Otsuka policy Preferred: Active leadership experiences *Up to 20% travel (trips to District, Regional and National Meetings) Come discover more about Otsuka and our benefit offerings; click here for more information PI116300742

Analytical Chemist US-TX-Burnet Job ID: 2019-6815 Type: Active Full-Time # of Openings: 1 Category: R&D Burnet Overview Entegris is growing! Come help design, deliver, and optimize the products that help produce some of the most important semiconductor devices in the world. Be a part of a team and organization that is pushing the boundaries of chemical manufacturing and analytical chemistry! As a Project Chemist, you will support several of our product development teams as well as be responsible for the metrology roadmap and analytical method development for the product area. In line with our values, which is fostering an environment of teamwork, you will have an opportunity to collaborate with technicians, scientists, engineers, leadership, sales & marketing and global technical team members. The ideal candidate will be results-oriented and continuous improvement-minded, with solid knowledge of chemistry, materials science & physics, and familiarity with semiconductor device materials, structures, and metrology. Responsibilities Responsible for analytical technical leadership for the R&D laboratory team in Burnet, TX; Uses product and testing expertise to collaborate with internal and external customers to determine root causes in product development and quality problems; Responds to customers’ feedback on technical problems and improve product value as well as customer satisfaction; Tests and helps develop new analytical methods for internal and external customers; Solves customers’ quality complaints and provide solutions to their technical issues; Participates in technology exchanges with customers by visiting and tele-conferencing; Promotes Entegris’ image by participating industrial conferences and seminar; Continuous training on the various analytical techniques and methods. Qualifications Masters of Science in chemistry, physics or engineering required, Ph.D. preferred; General lab instrument (HPLC, IC, GC, ICP-MS, ICP-AES) operations and maintenance experience preferred ICP-MS strongly preferred; Basic computer knowledge, including MS Office LIMS experience preferred; Prior experience working in a chemical / gas manufacturing environment preferred; Experience with applicable quality tools such as pareto, FMEA’s, SPC/SQC, histograms, trend analysis, process mapping, design of experiments, cause and effect diagrams, 8D problem solving methodology; Strong Expertise in chemical analysis related to blended cleans and advanced deposition materials; Demonstrated problem solving skills with a passion for learning and teaching; Self-starting leader with excellent communication and interpersonal skills; Ability to operate in a global environment; Ability to work effectively with cross-functional teams; Knowledge of proper safe handling/disposal of chemicals and ability to maintain a clean and safe workspace; Mandarin or Korean is a plus; Ability to travel 20% of time, some international. PI116300813

Jet Propulsion Laboratory Engineering Development Technician III US-CA-Pasadena Job ID: 2019-11321 Type: Temporary Full-Time # of Openings: 1 Category: Engineering *JPL - HQ Overview New ideas are all around us, but only a few will change the world. That’s our focus at JPL. We ask the biggest questions, then search the universe for answers—literally. We build upon ideas that have guided generations, then share our discoveries to inspire generations to come. Your mission—your opportunity—is to seek out the answers that bring us one step closer. If you’re driven to discover, create, and inspire something that lasts a lifetime and beyond, you’re ready for JPL. Located in Pasadena, California, JPL has a campus-like environment situated on 177 acres in the foothills of the San Gabriel Mountains and offers a work environment unlike any other: we inspire passion, foster innovation, build collaboration, and reward excellence. Responsibilities As an Engineering Technician, you will be working for the Applied Electromagnetics Group to provide engineering technician services that include the following: fabrication of electronics (boards and cables/harnesses); electronic packaging; module assembly; manufacturing engineering support; cryogenics systems assembly, refurbishment, and troubleshooting; RF high-power and low-power amplifier systems assembly, troubleshooting, and test verification. Some Challenges You Will Tackle Perform printed wiring board electronic assembly, hand soldering, connector pin crimping, cabling, chassis wiring, microelectronic assembly, and mechanical assembly. Fabricate and support the testing of DSN receivers, including: low-noise amplifier into complete cryogenic systems, including associated components such as corrugated feed horns. Assemble cryogenic systems including dewars, cold heads, compressors and vacuum pumps. Perform leak checks and repairs on vacuum systems, cryogenic piping, vacuum jacketed lines and LN2/Helium storage and delivery systems. Assemble, test, and document various high-power RF assemblies associated with DSN transmitter systems. Work on moderately difficult assignments; resolves issues and makes recommendations; may refer complex issues to higher levels: will support the design engineer(s) in assessing and recommending design modifications. Qualifications Typically requires a High School diploma with 8 years of related experience, or an Associates Degree with 4 years of related experience or a Bachelor's degree with 1 year of related experience. Advanced knowledge of electronic and mechanical fabrication techniques to fabricate and assemble complex mechanical, electronic, electromechanical, hybrid, cable harness assembly and microelectronics systems, devices, fixtures, parts or equipment. JPL soldering (Requirements for Soldered Electrical and Electronic Connections, IPC-J-STD-001CIS for Operator), JPL Critical Item Handling, JPL ESD Control, JPL Cleanroom fundamentals, and Crimping, Interconnecting Cables, Harnesses and Wiring (including IPC J-STD-001 Space Addendum (CIS) (Module 6) and IPC J-STD-001 Space Addendum CIT provides additional requirements beyond those issued in the IPC J-STD-001 Requirements for Soldered Electrical and Electronic Assemblies. Experience with mechanical fabrication, repair, and refurbishment of high-power RF, cryogenic and vacuum systems. Advanced understanding of work techniques, applicable policies, procedures and practices in planning, setup, repair and/or modification of mechanical, electronic or electro-mechanical systems, and specialized test equipment. Experience in working from schematics, rough sketches, diagrams, layouts or plans often requiring interpretation of the unique design. Possesses creativity and is capable to innovate and produce high-quality assemblies. Ability to work independently and collaboratively in a team environment. General understanding and application of standard principles, theories, concepts and techniques in amplifiers for low noise application in microwave subsystems. General knowledge of applicable industry standards in microwave/RF subsystems. Experience with mechanical design and fabrication. Necessary mechanical knowledge to assemble electrical boxes, and understanding of cryogenic valves and pumps. Desired Qualifications: Background and/or experience in microwave/RF engineering. Strong understanding of RF systems in the DSN. Desire to develop expertise in assembly of low-noise, cryogenically cooled amplifiers from both RF and mechanical design/packaging aspects. Caltech/JPL is an Equal Employment Opportunity (EEO) and affirmative action employer. It is the policy of Caltech/JPL to provide equal employment opportunities, actively recruit, and include for employment consideration all qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information. PI116300898

Oregon Health & Science University Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu. Location: US-OR-Portland Req ID: 2019-3243 Position Category: Research Position Type: Regular Full-Time Job Type: Faculty Department: Vollum Institute Salary Range: Commensurate with Experience HR Mission: Research Department Overview The Vollum Institute is a privately endowed research institute at Oregon Health & Science University dedicated to basic research that will lead to new treatments for neurological and psychiatric diseases. Vollum scientists have broad-ranging interests that coalesce around molecular neurobiology and cellular physiology. Their work has transformed the field of neuroscience and, in particular, have provided important advances in the study of synaptic transmission, neuronal development, neurotransmitter transporters, ion channels and the neurobiology of disease. Function/Duties of Position The responsibilities include but not limited to: Conduct and publish leading research with the focus on neuroscience relevant topics such as molecular and cellular neuroscience, molecular genetics, circuits and systems in model organisms, structural biology, and glial biology. Required Qualifications Ph.D. or M.D. required with at least several years of postdoctoral experience Strong record of research success and an interest in training graduate students Additional Details Submit curriculum vitae, a description of research plans and goals, and three letters of reference. All are welcome PI116299338

Oregon Health & Science University Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu. Location: US-OR-Portland Req ID: 2019-3242 Position Category: Research Position Type: Regular Full-Time Job Type: Faculty Department: Vollum Institute Salary Range: Commensurate with Experience HR Mission: Research Department Overview The Vollum Institute is a privately endowed research institute at Oregon Health & Science University dedicated to basic research that will lead to new treatments for neurological and psychiatric diseases. Vollum scientists have broad-ranging interests that coalesce around molecular neurobiology and cellular physiology. Their work has transformed the field of neuroscience and, in particular, have provided important advances in the study of synaptic transmission, neuronal development, neurotransmitter transporters, ion channels and the neurobiology of disease. Function/Duties of Position The responsibilities include but not limited to: Conduct and publish leading research with the focus on neuroscience relevant topics such as molecular and cellular neuroscience, molecular genetics, circuits and systems in model organisms, structural biology, and glial biology. Required Qualifications Ph.D. or M.D. required with at least several years of postdoctoral experience Strong record of research success and an interest in training graduate students Additional Details Submit curriculum vitae, a description of research plans and goals and three letters of reference. All are welcome PI116299357

Alexion Pharmaceuticals, Inc. Alexion is an Equal Opportunity/Affirmative Action Employer. Req ID: 17107 Job Category: Process Development Location: New Haven, CT Posting Date: December 12, 2019 Attention: If you are a current Alexion employee, please apply via Alexion's internal Life & Career portal . Note that you will need to be connected to the VPN if you are applying away from the office. Alexion does not contact candidates via instant messaging or chat tools. At no time will we ask candidates for fees associated with obtaining software, nor do we provide employees with a cashier's check to purchase new equipment. If you are contacted in this manner, please be aware that it is fraudulent, and please do not provide any information or money to these individuals. Applicants should only apply through this Alexion website. Any fraudulent activity should be reported to GSOC@alexion.com Position Summary Alexion's Global Product Development organization is seeking an experienced technical professional to drive the execution of a comprehensive development program for solid oral dosage drug product. The Scientist III, Small Molecule Drug Product Development will be a subject matter expert for solid oral dosage within Alexion. Responsibilities include driving relentless execution against an ambitious plan for drug product development, scale-up, and optimization, articulating timeline and resource constraints to Alexion management, providing technical leadership for development and manufacturing activities at third parties, and communicating impactful technical findings to a broad cross-functional team of stakeholders. Job Duties & Responsibilities Work through CMOs to drive the execution of a comprehensive solid oral dosage drug product development program spanning first-in-human clinical trials through process validation and regulatory submission. Ensure that a stage-appropriate level of process and product knowledge is maintained throughout development, such that a robust supply of drug product is maintained for clinical studies, through regulatory approval and commercial launch. Provide expert evaluation of the technical capabilities and quality systems of current and prospective CROs and CMOs. Build strong working relationships with third parties that meet Alexion's exacting standards for technical excellence and quality compliance. Own tech transfer to cGMP facilities. Partner with CMOs to diagnose and remediate process upsets. Partner with QA groups to support product impact assessments, facilitate root cause analyses, and establish CAPAs. Ensure CMO readiness for process validation, pre-approval inspection, and commercial launch. Provide on-site technical support during process validation, and as needed at earlier stages of development. Communicate key technical findings and challenges to a cross-functional team of stakeholders, including assessment of impacts to budget, timeline, quality, regulatory, and clinical supply. Partner closely with drug substance and analytical development colleagues in developing an integrated and holistic CMC control strategy, and in the preparation of regulatory documents. Essential Qualifications M.S. Chemical Engineer or Pharmaceutics with minimum 18-20 years experience with formulation development, process optimization, tech transfer, and in-plant manufacturing support for solid oral dosage drug product. Drive execution of formulation and process development activities at CMOs. Lead tech transfer to cGMP facilities. Up to 15% travel, with ability to work independently from remote locations. Expert understanding of cGMPs and regulatory guidances. Proficient in tools to facilitate process and product quality risk assessments. Partner with CMOs to diagnose and remediate process upsets. Partner with QA groups to support product impact assessments, facilitate root cause analyses, and establish CAPAs. Coordinate execution of late-phase development activities including univariate and multivariate process robustness studies, as well as process scale-up strategy. Ensure CMO readiness for process validation, pre-approval inspection, and commercial launch. Provide on-site technical support during process validation, and as needed at earlier stages of development. Provide expert technical insights supporting preparation of regulatory submission documents and responses to health authority queries. Preferred Qualifications Expertise in development of drug products targeted toward pediatric patient populations. Experience in planning and implementation of post-approval process and formulation changes. Expertise in development of amorphous solid dispersions, as well as other approaches for enabled formulations. Expertise in development of modified release drug products. Expertise in development of combination drug products. Expertise in multivariate data analysis, process analytical technologies, and first-principles modeling and simulation. Expertise in equipment design and process development to support continuous manufacturing. Passion for seeking out and evaluating new and emerging technologies. Cultivate relationships with third parties with the willingness to deploy innovative technologies that will improve cycle time, supply chain robustness, quality, and/or performance attributes of drug product. *LI-DI1 New Haven, CT, United States Some opportunities happen only once in a lifetime - like a job where you have the extraordinary opportunity to change lives. At Alexion, such opportunities arise through our unwavering mission to serve patients and families affected by rare diseases. These patients are our guiding star, and we act with integrity, urgency, and discipline because we know their lives are at stake. Alexion is a global biopharmaceutical company focused on serving patients and families affected by rare diseases through the discovery, development and commercialization of life-changing therapies. As the global leader in complement biology and inhibition for more than 20 years, Alexion has developed and commercializes two approved complement inhibitors to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) as well as the first and only approved complement inhibitor to treat atypical hemolytic uremic syndrome (aHUS), anti-acetylcholine receptor (AchR) antibody-positive generalized myasthenia gravis (gMG) and neuromyelitis optica spectrum disorder (NMOSD). Alexion also has two highly innovative enzyme replacement therapies for patients with life-threatening and ultra-rare metabolic disorders, hypophosphatasia (HPP) and lysosomal acid lipase deficiency (LAL-D). In addition, the company is developing several mid-to-late-stage therapies, including a second complement inhibitor, a copper-binding agent for Wilson disease and an anti-neonatal Fc receptor (FcRn) antibody for rare Immunoglobulin G (IgG)-mediated diseases as well as several early-stage therapies, including one for light chain (AL) amyloidosis and a second anti-FcRn therapy. Alexion focuses its research efforts on novel molecules and targets in the complement cascade and its development efforts on the core therapeutic areas of hematology, nephrology, neurology, and metabolic disorders. Alexion has been named to the Forbes' list of the World's Most Innovative Companies seven years in a row and is headquartered in Boston, Massachusetts' Innovation District. The company also has offices around the globe and serves patients in more than 50 countries. Further information about Alexion can be found at: www.alexion.com. As a leading employer in our industry, Alexion is proud to offer a highly competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. Alexion participates in E-Verify process. To learn more, please click on attached document(s) English / Spanish PI116292138

Jet Propulsion Laboratory Senior Research Data Scientist US-CA-Pasadena Job ID: 2019-11323 Type: Regular Full-Time # of Openings: 1 Category: Software and Computing Systems *JPL - HQ Overview New ideas are all around us, but only a few will change the world. That’s our focus at JPL. We ask the biggest questions, then search the universe for answers—literally. We build upon ideas that have guided generations, then share our discoveries to inspire generations to come. Your mission—your opportunity—is to seek out the answers that bring us one step closer. If you’re driven to discover, create, and inspire something that lasts a lifetime and beyond, you’re ready for JPL. Located in Pasadena, California, JPL has a campus-like environment situated on 177 acres in the foothills of the San Gabriel Mountains and offers a work environment unlike any other: we inspire passion, foster innovation, build collaboration, and reward excellence. Responsibilities Research Data Scientist opportunity available to work with JPL's Machine Learning & Instrument Autonomy Group. The team employs rigorous, explainable Machine Learning (ML) methods to support scientific data investigation on the ground, inform spacecraft operations teams in a time-critical setting, infuse new capabilities into JPL’s space missions, and extend the reach of scientists beyond Earth by creating autonomous “smart” instruments that can recognize and prioritize discoveries. We eschew “black box” ML, and often our trained models are created and examined explicitly to shed light on complex data and increase human insight rather than to automate a process. We collaborate with scientists, spacecraft operators, and engineers to identify novel ways that ML and data-driven science can help achieve their goals. Finally, we infuse ML solutions throughout JPL and NASA to bring about a richer, deeper, and more complete understanding of our universe from the Earth to the stars. We measure the success of our applied ML systems in terms of human hours saved, additional discoveries made, or new questions that may be addressed. We also frequently act as ambassadors to science and engineering areas not yet familiar with data-driven approaches by teaching, explaining, and offering assistance to those ready to receive it in the complex and often risk/change-averse arena of space exploration. Senior Research Data Scientist responsibilities include: Conduct R&D of ML and related technologies for application to science and engineering challenges Develop and lead algorithm and data processing methods for airborne and satellite remote sensing platforms, planetary surface missions, and novel instrument designs Collaborate with domain experts from a variety of natural science and space-related engineering fields Publicize practical and theoretical work through peer-reviewed conference, workshop, and journal papers Facilitate the infusion of high quality, data-driven technologies throughout JPL and NASA Provide strategic guidance on all aspects of data science at the group, section, division, and institutional level Drive the infusion of data-driven products into JPL missions, components, instruments, and processes Obtain competitive grant proposal funding, form multidisciplinary teams, and serve as Principle Investigator The Machine Learning & Insturment Autonomy Group is part of the Instrument Software and Science Data Systems Section which provides expertise across the domains of instrument operations and science data systems with a team of multidisciplinary engineers and technologists. Our engineering teams build and operate high performance data processing, management and analysis systems capable of handling petabyte scale datasets in support of science discovery, research, operations and applications. The Section supports JPL and NASA missions, as well as other science-based projects. Our research and technology development teams create new onboard and ground based technologies for data processing, analysis, modeling, reasoning, visualization, management, access and analytics that are infused into our data systems. Qualifications Typically requires degree in Computer Science, Electrical Engineering, or related technical discipline with a minimum of 9 years of experience, or a Master's with 7 years experience or a Ph.D with 5 years experience. Sustained record of high-quality ML and space data-oriented papers in respected, peer reviewed publications Demonstrated Principle Investigator leadership and independent, novel research capabilities Demonstrated success competitive proposal calls in space-related areas Active reviewer for major data science / remote sensing journals and conferences Broad knowledge of traditional and deep ML for time series, image, and spectral analysis Demonstrated examples of software that are written to be maintainable, reusable, and follows best practices Excellence in extracting meaningful science-relevant conclusions, identifying driving features, and performing relevant tradeoff analyses that inform data exploration, build intuition, and address specific mission needs Deep expertise in and dedication to rigorous validation and explainability for all analyses Strong written and oral communication skills including data visualization, presentation, and explanation of results Team-building mentality, can-do attitude, and relentless commitment to project success Significant programming experience with Python including NumPy / scikit-learn with high productivity Preferred Skills: Experience with software engineering best practices including unit and regression testing Optimizing and delivering algorithms to onboard, large-scale computing, or real-time critical systems Working knowledge of Earth Science / Atmospheric Science / Planetary Science / Physics / Astronomy / Geology Caltech/JPL is an Equal Employment Opportunity (EEO) and affirmative action employer. It is the policy of Caltech/JPL to provide equal employment opportunities, actively recruit, and include for employment consideration all qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information. PI116266542

Jet Propulsion Laboratory Electronic Development Technician II US-CA-Pasadena Job ID: 2019-11363 Type: Regular Full-Time # of Openings: 1 Category: Engineering *JPL - HQ Overview New ideas are all around us, but only a few will change the world. That’s our focus at JPL. We ask the biggest questions, then search the universe for answers—literally. We build upon ideas that have guided generations, then share our discoveries to inspire generations to come. Your mission—your opportunity—is to seek out the answers that bring us one step closer. If you’re driven to discover, create, and inspire something that lasts a lifetime and beyond, you’re ready for JPL. Located in Pasadena, California, JPL has a campus-like environment situated on 177 acres in the foothills of the San Gabriel Mountains and offers a work environment unlike any other: we inspire passion, foster innovation, build collaboration, and reward excellence. Responsibilities As an Engineering Development Technician, you will be a member of the Instrument Electronics Group and will report to the Group Supervisor. You will conduct and document activities on a variety of technical tasks such as assembly, disassembly, fabrication, test, calibration, measurement, maintenance, cabling and components, ground support equipment, specialized test equipment, modification, maintenance and certification of laboratory facilities and equipment. You will also ensure that the process, product, and environment comply with Laboratory protocols, government regulations, and professional standards. Additional duties include (but are not limited to): Apply advanced knowledge of electronics fabrication and assembly to fabricate and assemble complex mechanical, electronic or electro-mechanical systems, devices, fixtures, cabling parts or equipment & SMT (surface mount technology). Exercise training and experience in soldering components on circuit boards and for fabricating cables. Perform work in an ESD safe environment. Work from limited information, written or verbal instructions, schematics, rough sketches, diagrams, layouts, or plans often requiring interpretation. Recommend modifications to engineering designs as necessary. Provide project teams with facility and equipment logistics support during assembly, integration and test phases. NOTE: As a temporary position, this assignment may last up to 36 months in duration with approvals based on 12 months assignments. However, please note that you are not under any employment contract and your temporary employment status can be terminated at any time with or without notice. Qualifications Typically requires a High School diploma with a minimum of 6 years of related experience; Associates degree with a minimum of 1 years of work experience or Bachelors in a related field. Extensive knowledge and experience in handling of micro-assembly size items under microscope, soldering, etc. Good hand-eye coordination and manual dexterity, necessary to work with miniaturized systems or components. Experience with SMT (surface mount technology), fabricating high reliability circuits employing on surface mount components and testing. Building & mechanical assembly of flight electronic boards. Experience with machine tools including drill press and mill. Knowledge of basic computer skills such as e-mail, Microsoft word, and Excel. Experience reading electrical and mechanical drawings. Ability to work with multiple projects and discipline tasks within moderate to broad scope, including customers in a dynamic environment, occasionally many times within a day, and stay organized and focused. The individual must also be self-motivated and able to work independently with minimal supervision. Strong team player with good interpersonal and communication skills and the ability to work effectively in a team environment. Experience working in an ESD safe environment. Preferred Skills: JPL flight certifications for electrical and mechanical assembly, the individual should be able to be flight certified by NASA. Certifications in Electronic Development and/or testing. Extensive knowledge and experience in the application of troubleshooting techniques as applied to electronic and electromechanical fabrication and test. Extensive knowledge and experience with electronic test equipment and tools. Extensive knowledge and experience with company policies, procedures, and practices. Mechanical assembly skills. Experience with welding and bonding of gold plated items and wires. Prior aerospace industry experience. Experience building flight cabling. Caltech/JPL is an Equal Employment Opportunity (EEO) and affirmative action employer. It is the policy of Caltech/JPL to provide equal employment opportunities, actively recruit, and include for employment consideration all qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information. PI116266577

Otsuka Neuroscience Account Mgr US--Remote Sales Job ID: 2019-11070 Type: Full time # of Openings: 1 Category: Field Sales Otsuka Overview At Otsuka, we defy limitation, so that others can too. We have an unwavering belief in doing more. In transcending expectations. In going above and beyond—under any circumstances—for patients, families, providers, and for each other. It's this deep-rooted dedication that drives us to uncover answers to complex, underserved medical needs, so that patients can push past the limitations of their disease and achieve more than they thought was possible each and every day. We believe that the bigger the challenge, the bigger the opportunity. We are doing everything in our power to live up to our mission of creating new products for better health worldwide in two important therapeutic categories: neuroscience and nephrology. Our culture is rooted in our Japanese heritage and almost 100-year history. Otsuka-people live by the core principles of Jissho – the achievement, completion, and discovery of truth; and Sozosei – pursuing that which only Otsuka is capable of delivering. We approach our business and overcome challenges through perseverance, unconventional thinking and humility. Learn more about Otsuka Pharmaceutical Company on its global website at http://www.otsuka.co.jp/en . Learn more about Otsuka in the U.S. at www.otsuka-us.com . Disclaimer: This job description is intended to describe the general nature and level of the work being performed by the people assigned to this position. It is not intended to include every job duty and responsibility specific to the position. Otsuka reserves the right to amend and change responsibilities to meet business and organizational needs as necessary. Otsuka is an equal opportunity employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to their protected veteran or disabled status, or any protected status. Responsibilities We are committed to mental health and looking for Account Managers who share our passion to support the promotion and co-promotion of neuroscience products. Over the years, our innovations in schizophrenia and major depressive disorder (MDD) have advanced, and our knowledge of other mental health illnesses and disorders continues to grow. We are looking for individuals who are highly motivated, learning agile, and can grow in a Commercial organization. Otsuka-people who: Think differently by challenging conventional thinking Are intellectually curious and life-long learners Are effective, 'get it done' and have a sense of ownership Are comfortable with ambiguity, autonomy and recognize that innovation is at its best when people connect Are remarkable in their chosen field Key Job Expectations/Responsibilities: Can be counted on to exceed goals successfully, very bottom-line oriented, steadfastly pushes self and others for results Can quickly find common ground and solve problems for the good of all, can represent his/her own interests and yet be fair to others, can solve problems with peers, direct reports and matrix team members with a minimum of noise, is seen as a team player and is cooperative, easily gains trust and support of colleagues, encourages collaboration Summarizes complex situations or data sets into easily understood information Makes decisions using information gathered and develops others in their ability to organize their thoughts, identify patterns in data, and facilitate decision making Continually analyzes performance against plan and is proactive in planning sales activities to maximize customer calls and impact Evaluates the results of timelines and resource plans and recommends changes Coordinates with alliance company sales management team within region geography Manages key account coordination along with the District Managers to develop relationships leading to increased profitability and better patient outcomes Ability to sell a portfolio of products Compliance Management: Ensures full and complete compliance of all selling activities within the area of responsibility to OAPI standards and to all state and federal regulations Complies with the letter and spirit of all state and federal laws, regulations, and guidance as well as PhRMA Code on Interactions with Healthcare Professionals and OAPI standards and policies relating to all promotional activities Qualifications Required: 2 years of pharmaceutical sales experience and/OR 3-5 years of business to business outside sales experience Minimum of 1 year ranked in top 25% with overall sales Able to provide last 2 years of performance review documentation Willing to un-learn entrenched ways of doing things Ability to learn new and complex materials and concepts Demonstration of customer focus or patient centricity Thinks strategically; intuitively makes connections and associations Communicates effectively; strong and engaging facilitator Demonstrates managerial courage and strong professional presence Humility Bachelor of Arts (BA) or Bachelor of Science (BS) degree from an accredited four year college or university (or the equivalent if education obtained outside of the United States) Valid Driver's license and a good driving record under Otsuka policy Preferred: Active leadership experiences *Up to 20% travel (trips to District, Regional and National Meetings) Come discover more about Otsuka and our benefit offerings; click here for more information PI116266185

Oregon Health & Science University Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu. Location: US-OR-Portland Req ID: 2019-3170 Position Category: Research Position Type: Regular Full-Time Job Type: Research Department: Pathology Salary Range: Starting Range: $78,030-$109,242 Schedule: Primarily business hours/days HR Mission: School of Medicine Department Overview The Hansel Lab is a research laboratory situated in the Department of Pathology at Oregon Health & Science University (OHSU). Our research focuses on the development and progression of bladder cancer with an especial interest in the role of mammalian target of rapamycin (mTOR) signaling and its regulation of cytoskeletal changes and invasion. Our laboratory uses a combination of human tissue, in vitro, human ex vivo, and mouse models to delineate signaling pathway changes and impact on cellular behavior. Identification of mTOR targets in this setting will be used to develop new biomarker approaches to bladder cancer detection and new targeted approaches to arrest bladder cancer cell growth. Function/Duties of Position The Staff Scientist will be the laboratory lead in support of the lab's projects including assisting in the development and overview of study design and execution, co-authoring manuscripts and assisting with supervision of team members. Responsibilities include: Oversee experimental design and implement solution to problems Assist with the study design of basic and translational projects in bladder cancer Develop innovative approaches to research questions Help coordinate collaborative efforts with other OHSU and external laboratories Interpret experimental results and performs statistical analysis Participate in the dissemination of research findings, including co-authorship of manuscripts and preparation of presentations for scientific meetings Help lead the team and supervise junior lab members Oversee lab safety protocols and document control, IRB and IACUC documents and submissions Required Qualifications PhD in related field 5 years of relevant post-doctoral experience in a research laboratory Ability to develop research approaches to basic and translational projects in the laboratory Expertise in cell biology and molecular biology approaches, application of -OMICs technology, and knowledge of cell signaling approaches and animal models Highly motivated Database management skills Strong writing skills Preferred Qualifications Experience in project design, regulatory document control, manuscript and grant writing, and data interpretation Additional Details Apply here online. Please be sure to upload a cover letter and CV or resume. All are welcome PI116265459

Harvard University EEO Statement We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law. 11-Dec-2019 Statistical Analyst Harvard T.H. Chan School of Public Health 51266BR Job Summary The Department of Social and Behavioral Sciences (SBS) is an active unit with a mission to understand and intervene on the social determinants of health and health equity across the life-course.This mission is achieved through research to identify the social and behavioral determinants of health, development and evaluation of interventions and policies leading to the improvement of population health, and the preparation of professionals and researchers who will fill leadership positions in advocacy and public service. The department's educational mission is to train both scholars and practitioners: scholars whose research will illuminate basic social determinants of health and who will identify and test innovative social policy and service interventions; practitioners who are skilled in designing, implementing, and evaluating health-enhancing interventions in action settings. Job-Specific Responsibilities The Statistical Analyst will be responsible for managing, analyzing, and presenting analytic output for two NIH-funded research projects. One of the projects is focused on measuring and analyzing multiple types of discrimination, at multiple levels, in relation to diverse health outcomes. The other project is focused on social epigenomics in relation to racial discrimination, economic deprivation, neighborhood social and physical characteristics, and health inequities. Additional duties and responsibilities include, but are not limited to, the following: SAS and R programming for data management and analyses; may also be required to learn new programs Statistical programming, including regression and multi-level modelling Data visualization, interpretation, and presentation of study data; output may include tables, charts, graphs, scatterplots, and histograms for team meetings, scientific publications, and possibly scientific presentations Preparing text that summarizes, for scientific publications and possible future grants, the statistical methods used Performing other duties as assigned Familiarity with, and/or interest in, the types of social exposures that are being analyzed is helpful. In addition to technical skills, the successful candidate must have strong interpersonal and communication skills, and must have experience effectively managing competing deadlines and priorities. Regular attendance and participation in study research team meetings is also required. PLEASE NOTE: This position has a term appointment of 2 years from date of hire, with the possibility of extension. PLEASE NOTE: Finalists will be required to submit a writing sample, and sample of code via a skills assessment. Basic Qualifications Bachelor's Degree in biostatistics, statistics, epidemiology, public health, applied mathematics, computer science, or closely related field, and/or equivalent work experience, required 2+ years of related experience required Statistical programming experience in SAS and/or R required Strong database management and computer skills required PLEASE NOTE: Finalists will be required to submit a writing sample, and sample of code via a skills assessment. Additional Qualifications Master's degree in Biostatistics, Epidemiology, or a related quantitative population science strongly preferred Experience in data analysis for social epidemiologic research preferred Additional Information Harvard University requires pre-employment reference checks and background screenings. This position has a 90 day orientation and review period. The Harvard T.H. Chan School of Public Health does not provide visa sponsorship for administrative and staff positions. ---------- The Harvard T.H. Chan of Public Health is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment - including fostering respect for all, serving the greater good, and welcoming individuals from diverse backgrounds, experiences, and perspectives. To learn more about the Chan School's mission, objectives, and core values, please visit our website here . Harvard offers an outstanding benefits package including: Time Off: 3- 4 weeks paid vacation, paid holiday break, 12 paid sick days, 11.5 paid holidays, and 3 paid personal days per year. Medical/Dental/Vision: We offer a variety of excellent medical plans, dental & vision plans, all coverage begins as of your start date. Retirement: University-funded retirement plan with full vesting after 3 years of service. Tuition Assistance Program: Competitive tuition assistance program, $40 per class at the Harvard Extension School and discounted options through participating Harvard grad schools. Transportation: Harvard offers a 50% discounted MBTA pass as well as additional options to assist employees in their daily commute. Wellness Options: Harvard offers programs and classes at little or no cost, including stress management, massages, nutrition, meditation and complimentary health services. Harvard access to athletic facilities, libraries, campus events and many discounts throughout metro Boston. Join the Harvard T.H. Chan School of Public Health to support our mission of health research and education, and to be a part of the oldest institution of higher learning in the country! Job Function Research Sub Unit ------------ Location USA - MA - Boston Department Social and Behavioral Sciences Time Status Full-time Union 00 - Non Union, Exempt or Temporary Salary Grade 056 Pre-Employment Screening Education, Identity PI116260368