University of Pittsburgh
Pittsburgh, PA, USA
Med-Medicine - Pennsylvania-Pittsburgh - (23007230) The Department of Medicine, Division of Infectious Diseases is seeking to hire a Post Doctoral Associate. The post-doctoral candidate will be involved in "on-the-fly" time-resolved cryo-electron microscopy (EM) - a technique that facilitates visualization of novel protein conformations, including those transiently occurring during catalysis. The associate will apply this technology, with collaborators in the Department of Structural Biology, to address biologically and clinically relevant knowledge gaps in HIV-1 reverse transcriptase biology, with a specific focus on the incorporation of nucleosides and nucleoside inhibitors, nucleoside inhibitor resistance, and the relationship between DNA synthesis and ribonuclease H activity. The candidate's research will include protein expression, purification, and biophysical characterization of polymerase enzymes. It is anticipated that the candidate will also provide oversight to either a...