Research Scientist

  • Harvard University
  • Boston, MA, USA
  • Nov 21, 2019

Job Description

Harvard University

EEO Statement
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law.

Research Scientist
Harvard Medical School

Job-Specific Responsibilities
We are a team of research scientists in the Harvard Medical School Department of Neurobiology dedicated to repurposing natural mechanisms of gene regulation to engineer precision viral vectors for gene therapy. We employ PESCA, a single-cell screening platform developed in-house, to sift through the mammalian genome and identify -- on-demand -- regulatory elements capable of driving optimal patterns of viral transgene expression to address a wide range of diseases. We believe that such elements are transformative and essential technologies in the world of gene therapy and that our approach and expertise uniquely position us at the forefront of next-generation viral vector design. Our collective mission is to employ these elements to create novel viral vectors that unlock the potential of gene therapy to cure genetic diseases with severe unmet need.

We are recruiting a full-time Research Scientist to join our team, whose primary responsibility will be to collaboratively develop and then drive multiple iterations of the PESCA pipeline simultaneously while keeping progress within projected timelines. Day-to-day responsibilities include supervising and managing 2-3 pre-doctoral research assistants (RAs), as well as interpreting and troubleshooting the RAs' experimental results, to ensure continued progress on all projects. The work will involve the application of cutting-edge technologies such as single-cell RNA-seq and ATAC-seq, and interested applicants should be sufficiently experienced in wet lab work that they can capably perform all steps of the PESCA pipeline, so as to advise RAs efficiently. The advertised position will also entail coordinating new and existing high- budget commercial partnerships and high-level multitasking to keep these simultaneously ongoing projects on track.

To these ends, we are seeking highly motivated individuals with strong scientific backgrounds, capable of efficient experimental planning, delegation, and management, who are excited by the prospect of pushing multiple projects to completion simultaneously in a fast-paced academic setting. The position will report directly to our core group of scientific leadership, offering a unique opportunity to play a lead role in developing promising new viral vectors of high therapeutic potential as part of a dynamic research group within the highly collaborative scientific environment that is the HMS Department of Neuroscience.

Basic Qualifications
Ph.D. in biological sciences; 5+ years of related hands-on wet lab experience.
Additional Qualifications
Interested individuals should be capable of performing any experiment in the PESCA pipeline, although the need should rarely arise as research assistants will perform the majority of bench experiments:
* Next-generation sequencing and library preparation (ATAC-seq, scRNA-seq, snRNA-seq)
* Molecular biology techniques including PCR, RT-PCR, ddPCR, and cloning
* Sequence design (Oligo/primer/gBlock) and analysis (Benchling, Snapgene, APE, etc.)
* Mouse colony maintenance
* Strong organizational and documentation skills

Good time management and rigorous scheduling, as all projects must progress simultaneously.
3+ years managing multiple high-budget projects, in industry or academic setting.
Good interpersonal and collaborative skills, to maintain a friendly but professional working environment.
Strong scientific communication skills, to keep project supervisors informed Strong presentation skills, to present data to academic
and industry collaborators Familiarity with Python and R.
Background in gene therapy or clinically relevant fields.
Additional Information
This is a 12-month term appointment with the possibility of renewal contingent on funding.

Offer contingent upon successful completion of a pre-placement medical evaluation.

Harvard offers an outstanding benefits package including:

Time Off: 3 - 4 weeks paid vacation, paid holiday break, 12 paid sick days, 11.5 paid holidays, and 3 paid personal days per year.

Medical/Dental/Vision: We offer a variety of excellent medical plans, dental & vision plans, all coverage begins as of your start date.

Retirement: University-funded retirement plan with full vesting after 3 years of service.

Tuition Assistance Program: Competitive tuition assistance program, $40 per class at the Harvard Extension School and discounted options through participating Harvard grad schools.

Transportation: Harvard offers a 50% discounted MBTA pass as well as additional options to assist employees in their daily commute.

Wellness options: Harvard offers programs and classes at little or no cost, including stress management, massages, nutrition, meditation, and complementary health services.

Harvard access to athletic facilities, libraries, campus events and many discounts throughout metro Boston.

The Harvard Medical School is not able to provide visa sponsorship for this position.

Job Function

Sub Unit

USA - MA - Boston


Time Status

00 - Non Union, Exempt or Temporary

Salary Grade

Appointment End Date

Pre-Employment Screening
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